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John Travolta's appearance in American Crime Story has fans worried the Pulp Fiction star's face might be melting.

Travolta, 62, plays OJ Simpson's lawyer Robert Shapiro in the show, a fictional account of the the real-life murder trial of the famous footballer.

But Travolta's appearance has sparked some hilarious reactions from fans.

In the show, which screens on Sky TV's SoHo channel on Wednesdays at 8.30pm, the actor sports slicked back hair, a deep tan, bushy eyebrows and stern but camp range of comical expressions.

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Fans have asked what's happened to Travolta's face, and queried whether the star had been under the knife.

"How freaked out are you about John Travolta's face?" asked one fan.

"It's worth watching The People vs OJ Simpson just to see John Travolta try to act with his face tied behind his head," joked another.

A third compared his appearance to a Mr Potato Head toy with mix-and-match features.

Cuba Gooding Jr, who plays Simpson in the show, told People Travolta was his favourite co-star of all time.

"Besides singing with him to entertain the gallery of the courtroom, I just enjoyed hearing stories of his life from [sitcom] Welcome Back, Kotter to travelling with Michael Jackson," he said.

- nzherald.co.nz