During Queen's Birthday last year there were four fatal crashes resulting in seven deaths, and 17 crashes involving serious injuries. A further 59 crashes caused minor injuries.
Mr Cliff said police would also be focusing on alcohol, restraints and speed this weekend, with a variety of tactics in place, including routine breath testing and a lowered 4 km/h speed tolerance.
"The lowered speed tolerance was introduced at Queen's Birthday Weekend three years ago, and has been in place for all holiday weekends since. In that time, it has had a positive effect on driver behaviour, with a decrease in crashes since its introduction. That translates to fewer people killed, maimed or injured.
"The message to all motorists this holiday weekend is really very simple - drive to the conditions, pay attention, don't drink and drive and make sure you are wearing your seat belt."
Queen's Birthday weekend 2013 officially starts at 4pm Friday 31 May and ends 6am Tuesday 4th June.