Emergency services are at the scene of a two-car crash on State Highway 41, near Turangi.
A police spokeswoman said one person had serious injuries.
A St John spokeswoman said the other person was moderately injured and had been taken to Taumarunui Hospital.
SH41 is down to one lane near the intersection with Pukawa Rd, Omori.
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The crash happened about 2.30pm.
The Serious Crash Unit has been called.