Emergency services are at the scene of a two-car crash on State Highway 41, near Turangi.
A police spokeswoman said one person had serious injuries.
A St John spokeswoman said the other person was moderately injured and had been taken to Taumarunui Hospital.
SH41 is down to one lane near the intersection with Pukawa Rd, Omori.
The crash happened about 2.30pm.
The Serious Crash Unit has been called.