Charlie Sheen is under investigation after he allegedly threatened his dentist with a knife, according to a US report.

Officers from the Los Angeles Police Department are investigating claims the Anger Management star was involved in a scuffle with his personal dentist and an oral surgeon while receiving treatment for an abscess, reports celebrity website TMZ.com.

The dental technician in the room at the time of the incident has told TMZ that Sheen "went insane" when she placed a mask over his face to administer nitrous oxide.

She says Sheen began flailing his arms and struck her.

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The technician also told TMZ that the actor was high on rock cocaine at the time and pulled a knife on the dentist.

Sheen was contacted for comment but did not respond.

- WENN