An EgyptAir flight from Paris to Cairo carrying 59 passengers and 10 crew disappeared from radar today, the airline said.
The Airbus A320 most likely crashed into the sea, Ihab Raslan, a spokesman for the Egyptian civil aviation agency, told SkyNews Arabia.
He said the plane was about to enter Egyptian airspace when it disappeared from radar.
The airline, however, said it had vanished 16 kilometers after it entered Egyptian airspace.
The disappearance is the latest in a number of recent air disasters:
Metrojet flight 9268
On October 31 last year, Metrojet flight 9268 bound for St Petersburg exploded over the northern Sinai, 23 minutes after take off from Egypt's Sharm el-Sheikh airport.
The Airbus had 217 passengers, mostly Russians, and seven crew members on board.
After initially rejecting the suggestion, Russia later admitted the plane was brought down by a homemade bomb on board.
Germanwings flight 9525
On March 24 last year Germanwings Flight 9525, with 144 passengers and six crew onboard, began descending one minute after the last routine contact with air traffic control.
According to an investigation, co-pilot Andreas Lubitz deliberately crashed the plane into the Alps. He had been treated for depression in the past.
Malaysia Airlines flight MH17
On July 17, 2014, Malaysia Airlines flight MH17 from Amsterdam to Kuala Lumpur crashed in Donetsk Oblast, Ukraine, killing all 298 people on board, including 38 Australian citizens and residents.
A Dutch civil investigation concluded that the Boeing 777 was downed by a Soviet-designed Buk surface-to-air missile. Russian-backed rebels have been blamed for the incident.
This week NSW State Coroner Michael Barnes handed down his findings into the crash, describing it as "gross mass murder" deliberately perpetrated by "a person or persons not yet known".
Malaysia Airlines flight MH370
On May 8, 2014, Malaysia Airlines flight 370 went missing about one hour into its journey from Kuala Lumpur to Beijing, while it was flying over the South China Sea. The Boeing 777 was carrying 12 Mayalsian crew and 227 passengers, including six Australians.
Its disapperance sparked a multinational search effort and its fate has remained a mystery. Last week, Australian authorities said pieces of debris washed up in South Africa and Mauritius were "almost certainly" from MH370.
Air France flight 447
Air France Flight 447 from Rio de Janeiro to Paris crashed into the Atlantic Ocean on June 1, 2009, killing all 228 people onboard.
It took nearly two years to find the plane's black boxes, and an investigation uncovered recorder information reaveling one of the pilots shouted "F**k, we're dead" as the plane went down.
AirAsia flight QZ8501
AirAsia flight QZ8501 was flying between Surabaya, Indonesia, and Singapore when it disappeared from radar on December 28, 2014. The plane had crashed into the Java Sea during bad weather, killing all 155 passengers and seven crew onboard.
Pakistan International Airlines flight 404
On August 25 in 1989 Pakistan International Airlines Flight 404, which had 54 passengers and crew on board, disappeared after taking off from Gilgit, Pakistan.
It's thought the aircraft may have crashed in the Himalayas, but no wreckage has ever been found.