Nasa's Curiosity rover, the biggest, most sophisticated robotic explorer ever built, blasted off on Saturday on a journey to Mars, where it will hunt for signs life once existed there.
Curiosity, which is the size of a large car and weighs in at one ton, has a laser beam for zapping interesting rocks and a tool kit for analysing their contents.
It carries a robotic arm, a drill, and a set of 10 science instruments including two colour video cameras.
Sensors will enable it to report back on the Martian weather and the levels of radiation in the atmosphere - important data for Nasa as it devises future human exploration missions.
Known formally as the Mars Science Laboratory (MSL), the spacecraft launched at 10.02 am local time atop an Atlas V rocket to begin its nearly nine-month trip to the Red Planet.
"Liftoff of the Atlas V with Curiosity, seeking clues to the planetary puzzle about life on Mars," said Nasa commentator George Diller as the white rocket soared skyward from the Florida space pad.
The most advanced machine yet to roam the surface of Earth's nearest neighbour cost US$2.5 billion to construct and launch, and has been described by Nasa as "a dream machine."
It is powered by nuclear fuel and is about twice the size of Nasa's twin solar-powered rovers Spirit and Opportunity that landed on Mars in 2004.
Scientists hope it will return valuable information about the past, present and future habitability of Mars to help the US space agency plan a human mission there, perhaps by the 2030s.
One of the key instruments on board is a joint French-US project called the Chemistry and Camera investigation, which can emit a laser beam with the energy of a million light bulbs and tell scientists what makes up a Martian rock.
"It's like an arm that can reach out up to eight metres away, brush something off, analyse it, actually look at the weathering surfaces and the interior of the rock at the same time," said Roger Wiens, principal investigator.
The rover's robotic arm, meanwhile, can drill into the ground or into rocks to create a powder, and a mobile chemistry lab on board can sift through the powder and tell scientists back on Earth what it contains.
The landing spot for Curiosity, the Gale Crater near Mars' equator, was chosen after lengthy study because it contains a five-kilometre high mountain and many layers of sediment that could reveal a lot about the planet's wetter past.
"It is going to look for places that are habitable either in the past or potentially even in the future or currently," said Mary Voytek, director of Nasa's Astrobiology Program.
The crater itself is at a low elevation so scientists believe that if water ever did pool on Mars, it likely found its way there. Everywhere that water exists on Earth, so does some form of life.
First, the rover has to travel 570 million km, arrive intact and survive an elaborate rocketed-powered sky crane landing.
The project is meant to last two Earth years, or one full Martian year, but Nasa hopes that like some of its other rovers in the past, Curiosity will outlive its expected potential.
Opportunity is still returning information to Earth-bound researchers who finally lost contact with its companion, Spirit, last year.
About a dozen Mars missions have been launched in the past three decades by global space agencies, but only about half have succeeded. Nasa's exploration of Mars began with the 1976 landing of the Viking spacecraft.
"Viking did the best it could, but it could only see a couple of samples. MSL is going to look at tons of samples," said Pamela Conrad, deputy principal investigator of Nasa's sample analysis.
"Mars very easily could have produced life," she said. "Mars could very easily have evolved the complex chemistry that is necessary to be a habitable environment."