We all know a vacation feels great - but now there's medical research to back it up.
According to a new study, retreating to a relaxing resort eases stress, rejuvenates cells, and combats the effects of ageing.
If you can't get away, try meditation: the same paper found a short spell of self-reflection boosts your metabolism, immune function, and stress response long-term.
Researchers from the Icahn School of Medicine at Mount Sinai, the University of California and Harvard Medical School followed 94 healthy women aged from 30 to 60 years old, who all spent a week on vacation at the same resort.
Half of the group followed a meditation program including mantra meditation, yoga and self-reflection exercises.
The scientists also studied a group of 30 meditators who were already signed up for the week-long retreat.
Blood samples were collected from participants, as well as surveys, before and after their stay.
The samples were tested for biomarkers associated with stress, cell health and ageing.
Surveys were also collected one month and 10 months after the experience.
The scientists studied changes in 20,000 genes in all three groups to establish which genes were subject to changes before and after the week-long break.
Significant changes were observed in novice meditators, experienced meditators and vacations after one week at the resort.
The scientists put this down to the "vacation effect," brought about in relaxing environments.
The most notable changes were found in genes relating to stress response and immune function.
The benefits strongly increased for experienced meditators during the vacation period.
When asked about their well-being one month after the experience, all participants reported feeling better.
However, the novice meditators experienced fewer symptoms of depression and lower stress levels long-term than the vacationers who didn't meditate.
The psychological effects also appeared to be lasting.
The scientists suggest that meditation could help improve metabolism by protecting cells long-term, whereas classic vacations may favor more short-term improvements in mental well-being.
"Meditation is one of the ways to engage in restorative activities that may provide relief for our immune systems, easing the day-to-day stress of a body constantly trying to protect itself. The prediction is that this would then lead to healthier aging," said Rudolph Tanzi, professor of neurology at Harvard University.
The study was published in the journal Translational Psychiatry, published by Nature.