Tyson Fury's world heavyweight title rematch with Wladimir Klitschko has been cancelled for a second time, with Fury's management releasing a statement saying he has been "declared medically unfit to fight".
The pair were due to meet in Manchester on October 29, with Fury defending the WBA and WBO heavyweight belts he took off Klitschko last November.
One attempt at a rematch has already been abandoned because of an ankle injury sustained by Fury and it is now understood the fight will be called off for a second time.
After Fury's injury it then emerged that UK-Anti Doping (UKAD) had charged the champion, over a urine sample taken in February 2015, and his cousin Hughie with a doping offence.
It was alleged the sample - taken nine months before his defeat of Klitschko - contained traces of the banned substance nandrolone. Fury was provisionally suspended, but that ban has since been lifted, and his legal team said they would be suing UKAD over the allegations.
His hearing will be held in November.
Fury was last week due to attend a press conference with Klitschko, but failed to show up, with his manager citing car problems.
There was no comment from either camp on Friday.