Hurricanes captain Dane Coles and wings Nehe Milner-Skudder and Cory Jane must pass fitness tests before being considered to play the Blues at Eden Park on Friday.
Coles, who has missed the opening two rounds of the season due to hamstring and calf strains, has been bracketed with young hooker Leni Apisai.
The right wing spot has been left open with Milner-Skudder recovering from a bruised knee suffered during the opening round loss to the Brumbies and Jane working through concussion protocols after taking a knock against the Highlanders in Dunedin.
Depending on who is available, the No 14 jersey and the final bench spot could go to Milner-Skudder, Jane, Jason Woodward or Pita Ahki.
Hurricanes coach Chris Boyd said the sensible option was to err on the side of caution with all three injuries.
"We won't start guys unless they are 100 per cent fit and ready to go and we won't know if that's the case until they get through a full training run without any issues.
"We've already seen the New Zealand derby matches are tough battles of attrition and we expect the Blues to be highly motivated, as are we, for this match."
Injuries aside, Boyd has again stuck largely with the same team that lost 17-16 to the Highlanders in Dunedin.
Coles, if fit, would be the only change in the pack and would start alongside his Poneke club mate loose head prop Reggie Goodes, who will play his 50th match for the Hurricanes.
Goodes made his debut as a substitute against the Chiefs in Hamilton in 2012 and since then has missed just 11 Super Rugby matches.
The Hurricanes squad to play the Blues at Eden Park on Friday, March, 11 is:
15 James Marshall
13 Vince Aso
12 Ngani Laumape
11 Julian Savea
10 Beauden Barrett
9 TJ Perenara
8 Victor Vito
7 Ardie Savea
6 Brad Shields
5 Mark Abbott
4 Blade Thomson
3 Jeff Toomaga-Allen
2 Dane Coles/Leni Apisai
1 Reggie Goodes
Reserves: Apisai/Ricky Riccitelli, Chris Eves, Loni Uhila, Vaea Fifita, Callum Gibbins, Jamison Gibson-Park, Willis Halaholo, TBA.