Two people have been seriously hurt in a crash between a car and a motorcycle on Auckland's North Shore, police say.

The pair were taken to hospital by ambulance. Two other people had minor injuries.

The vehicles collided near the corner of Mokoia Rd and Chelsea View Drive in the suburb of Chatswood around 4.40pm.

Police said the serious crash unit was investigating and Mokoia Rd would be closed until at least around 8pm.

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Diversions were in place around 6pm and delays were expected.