Unlocking the mystery of ageing - science is getting close

Researchers are closer to unlocking the mystery of ageing.Photo / Thinkstock
Researchers are closer to unlocking the mystery of ageing.Photo / Thinkstock

Swiss researchers say they're a step closer to unlocking the mystery of ageing, after discovering the impact of a longevity gene in mice and then managing to extend the life-span of worms by 60 per cent thanks to a basic antibiotic treatment.

"They were not only living longer, but were also more fit," said Johan Auwerx in a video released by the Ecole Polytechnique Federale de Lausanne (EPFL), a cutting-edge Swiss research institute.

The findings of Auwerx's team have been published in the scientific journal Nature.

The goal of the research was to work out why certain individuals of the same species can have a far longer life-span than others.

"Our lab has for some time been using a complex genetic reference population of mice, which mimic the human population, to study ageing," said Auwerx.

The scientists started by examining mice's mitochondria - a cell's version of a power plant - and uncovered a group of three genes that affected the animals' life-span via their speed of functioning.

Those whose genes were 50 per cent slower lived some 250 days longer, or about 30 per cent of a mouse's lifetime.

"Based on this observation, we switched model, and started validating this experimentally in a worm," said Auwerx.

"Knocking down the same proteins, we could see an up to 60 per cent extension of worm life-span," he added.

Auwerx underlined that since mitochondria are bacteria living within cells, his team then experimented with antibiotics, which target bacteria.

"We could see that treating the worms with the antibiotics also mimicked the genetic effects, and they also lived 60 per cent longer," from 19 days to 30, he explained.

Mitochondria transform nutrients into various kinds of protein, and several previous studies have suggested that they may be the motor of ageing.

The Swiss team, working with counterparts in the Netherlands and United States, managed to identify the specific gene involved in the process and work out how variations in protein could affect life-span.

The researchers underlined that further studies would be needed to confirm whether antibiotics could be used to rein in ageing in mammals.


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