Hollywood's most popular actors haven't held back in their opposition to US President Donald Trump and his newly imposed immigration ban at the Screen Actors Guild Awards.

Emma Stone, Bryan Cranston, Ashton Kutcher and Julia Louis-Dreyfus attacked President Donald Trump at the SAG Awards - but one speech stole the show.

The crowd erupted when Stranger Things' win for Best Ensemble in a Drama Series was perhaps the biggest surprise of the night, especially since it took out none of the individual prizes.

Actor David Harbour's acceptance speech was similarly unexpected, but equally well-received.

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"This is unreal. I'd just like to say that with all that's going on tonight, it's hard to celebrate the already celebrated Stranger Things.

"We are united in that we are all human beings and we're all here together on this painful and mysterious ride that is being alive."

"We will repel bullies, we will shelter freaks and outcasts, we will hunt monsters, and when we are lost, we will punch some people in the face, and we will do it all with soul, with heart and with joy. We thank you for this responsibility."

Kutcher opened the ceremony by welcoming everyone watching at home and then saying angrily, "... and everyone in airports that belong in my America."

Kutcher's reference to immigration restrictions imposed by Trump that have excluded immigrants from seven nations and tied up others seeking entry into the country drew thunderous applause.

Loud cheers greeted statements denouncing the new immigration restrictions by Louis-Dreyfus, and a celebration of diversity by Taylor Schilling, who spoke after her series Orange is the New Black won best comedy series.

Scandal actress Kerry Washington addressed that criticism during the ceremony's introduction. She told the audience, "Actors are activists no matter what."

During the ceremony, the whole room erupted and yelled out "Power to the People".

The two biggest shock wins of the night were Hidden Figures, which got the Best Picture award, and Denzel Washington's gong for his role in Fences.