The wife of former Eagles band member Randy Meisner was killed when a rifle she was handling accidentally discharged and shot her in the head, Los Angeles police say.

Police said on Monday officers found 63-year-old Lana Rae Meisner dead on Sunday from a single gunshot wound at the couple's home in the San Fernando Valley.

Investigators say Lana Rae Meisner lifted the rifle from a storage case when another item inside shifted and hit the trigger, causing the gun to fire.

Officials say police had responded to the home earlier Sunday and took a domestic violence incident report.

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Randy Meisner co-founded the Eagles and co-wrote and sang the hit Take It To the Limit.

He played bass and guitar and left the band in 1977.

- AAP